At AIMSS, we endeavour to develop novel therapies and interventions at the basic science level, to steadfast its translation into the clinic. Under the Bone – Biomedical and Translational Program, we are working on a few interesting projects including the search for novel bone anabolic(s) (bone forming agent(s)), identifying bone disorders by measuring a rare population of cells (circulating osteoprogenitor cells – COP cells), and developing a novel animal model that could facilitate in understanding Inflammatory Bowel Disease (IBD) and association of bone degradation with this disease. We are also working toward understanding the role of vitamin D in protecting our bones from the fat attack (adipocytes (fat cells) in the bone that decrease bone strength), and also have research focus in exploring novel molecules as candidates for use against bone and muscle degradation.
Identifying novel osteoanabolics and their mechanism of action
Mitigating age-associated deleterious effects of adipocytes in ageing bone and muscle
Understanding mechanisms of the development of bone pathology associated with chronic intestinal inflammation