We have considerable experience conducting clinical trials of new and current pharmaceuticals on fracture prevention and bone mineral density, the effect of calcium, vitamin D3 and exercise on bone structure, population-based studies of osteoporosis including fracture rates, bone mineral density, and physical activity, and the prevalence and effect of Vitamin D deficiency and its treatment.
The Bone Density Unit (through Western Health and The University of Melbourne) offers diagnostic tools to support a comprehensive platform for bone health assessment, obesity assessment and visualisation of calcification in the abdominal aorta that can indicate heart disease.
The bone density unit boasts a DXA (Dual-emission X-ray absorptiometry) densitometer, used primarily to evaluate bone mineral density and total body composition, and pQCT (Peripheral quantitative computed tomography) for measuring peripheral bone mineral density, volumetric bone mineral density, plus other measures such as the stress-strain index (SSI) and the geometry of the bone. The bone density unit is available to both clinical and research patients.
Some recent publications from our researchers include:
Barton, C. J., P. Levinger, K. M. Crossley, K. E. Webster and H. B. Menz (2012). "The relationship between rearfoot, tibial and hip kinematics in individuals with patellofemoral pain syndrome." Clin Biomech (Bristol, Avon) 27(7): 702-705.
Bischoff-Ferrari, H. A., W. C. Willett, E. J. Orav, E. J. Oray, P. Lips, P. J. Meunier, R. A. Lyons, L. Flicker, J. Wark, R. D. Jackson, J. A. Cauley, H. E. Meyer, M. Pfeifer, K. M. Sanders, H. B. Stähelin, R. Theiler and B. Dawson-Hughes (2012). "A pooled analysis of vitamin D dose requirements for fracture prevention." N Engl J Med 367(1): 40-49.
Brennan, S. L., F. M. Cicuttini, G. C. Nicholson, J. A. Pasco, M. A. Kotowicz and A. E. Wluka (2012). "Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women." Ann Rheum Dis 71(6): 1000-1003.
Brennan, S. L., T. Stanford, A. E. Wluka, M. J. Henry, R. S. Page, S. E. Graves, M. A. Kotowicz, G. C. Nicholson and J. A. Pasco (2012). "Cross-sectional analysis of association between socioeconomic status and utilization of primary total hip joint replacements 2006-7: Australian Orthopaedic Association National Joint Replacement Registry." BMC Musculoskelet Disord 13: 63.
Brennan, S. L., T. Stanford, A. E. Wluka, R. S. Page, S. E. Graves, M. A. Kotowicz, G. C. Nicholson and J. A. Pasco (2012). "Utilisation of primary total knee joint replacements across socioeconomic status in the Barwon Statistical Division, Australia, 2006-2007: a cross-sectional study." BMJ Open 2(5).
Brennan, S. L. and G. Turrell (2012). "Neighborhood disadvantage, individual-level socioeconomic position, and self-reported chronic arthritis: a cross-sectional multilevel study." Arthritis Care Res (Hoboken) 64(5): 721-728.
Brennan, S. L., T. M. Winzenberg, J. A. Pasco, A. E. Wluka, A. G. Dobbins and G. Jones (2012). "Social disadvantage, bone mineral density and vertebral wedge deformities in the Tasmanian Older Adult Cohort." Osteoporos Int., online first 15 November 2012
Brennan, S. L., A. E. Wluka, H. Gould, G. C. Nicholson, W. D. Leslie, P. R. Ebeling, B. Oldenburg, M. A. Kotowicz and J. A. Pasco (2012). "Social determinants of bone densitometry uptake for osteoporosis risk in patients aged 50yr and older: a systematic review." J Clin Densitom 15(2): 165-175.
Crisp, A., T. Dixon, G. Jones, R. G. Cumming, L. L. Laslett, K. Bhatia, A. Webster and P. R. Ebeling (2012). "Declining incidence of osteoporotic hip fracture in Australia." Arch Osteoporos 7(1-2): 179-185.
Daly, R. M., C. Gagnon, Z. X. Lu, D. J. Magliano, D. W. Dunstan, K. A. Sikaris, P. Z. Zimmet, P. R. Ebeling and J. E. Shaw (2012). "Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: a national, population-based study." Clin Endocrinol (Oxf) 77(1): 26-35.
Damasiewicz, M. J., D. J. Magliano, R. M. Daly, C. Gagnon, Z. X. Lu, P. R. Ebeling, S. J. Chadban, R. C. Atkins, P. G. Kerr, J. E. Shaw and K. R. Polkinghorne (2012). "25-hydroxyvitamin D levels and chronic kidney disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) study." BMC Nephrol 13: 55.
Fihn, S. D., M. B. McDonell, P. Diehr, S. M. Anderson, K. A. Bradley, D. H. Au, J. A. Spertus, M. Burman, G. E. Reiber, C. I. Kiefe, M. Cody, K. M. Sanders, M. A. Whooley, K. Rosenfeld, L. A. Baczek and A. Sauvigne (2004). "Effects of sustained audit/feedback on self-reported health status of primary care patients." Am J Med 116(4): 241-248.
Gagnon, C., Z. X. Lu, D. J. Magliano, D. W. Dunstan, J. E. Shaw, P. Z. Zimmet, K. Sikaris, P. R. Ebeling and R. M. Daly (2012). "Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab)." J Clin Endocrinol Metab 97(6): 1953-1961.
Ebeling PR, DavenportG, Evans S and Mitchell P (2012). “Osteoporosis challenges”. Aust. Fam. Phys. 41:4.
Gianoudis, J., C. A. Bailey, K. M. Sanders, C. A. Nowson, K. Hill, P. R. Ebeling and R. M. Daly (2012). "Osteo-cise: Strong Bones for Life: Protocol for a community-based randomised controlled trial of a multi-modal exercise and osteoporosis education program for older adults at risk of falls and fractures." BMC Musculoskelet Disord 13(1): 78.
Gould, H., S. L. Brennan, G. C. Nicholson, M. A. Kotowicz, M. J. Henry and J. A. Pasco (2012). "Calcaneal ultrasound reference ranges for Australian men and women: the Geelong Osteoporosis Study." Osteoporos Int.
Haskelberg, H., J. F. Hoy, J. Amin, P. R. Ebeling, S. Emery, A. Carr and STEAL Study Group (2012). "Changes in bone turnover and bone loss in HIV-infected patients changing treatment to tenofovir-emtricitabine or abacavir-lamivudine." PLoS One 7(6): e38377.
Hua, B., E. Abbas, A. Hayes, P. Ryan, L. Nelson and K. O'Brien (2012). "Reliability of chinese medicine diagnostic variables in the examination of patients with osteoarthritis of the knee." J Altern Complement Med 18(11): 1028-1037.
Hua, B., E. Abbas, A. Hayes, P. F. Ryan, L. Nelson and K. O'Brien (2012). "Reliability of the Eight Guiding Principles and Syndrome Diagnosis in Chinese Medicine Diagnosis of Patients with Knee Osteoarthritis." J Altern Complement Med.
Karmakar, C., A. Khandoker, R. Begg and M. Palaniswami (2012). "Understanding ageing effects using complexity analysis of foot-ground clearance during walking." Comput Methods Biomech Biomed Engin.
Laker, R. C., M. E. Wlodek, G. D. Wadley, L. A. Gallo, P. J. Meikle and G. K. McConell (2012). "Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1α in adulthood." Am J Physiol Endocrinol Metab 302(10): E1221-1230.
Leslie, W. D., S. L. Brennan, H. J. Prior, L. M. Lix, C. Metge and B. Elias (2012). "The contributions of First Nations ethnicity, income, and delays in surgery on mortality post-fracture: a population-based analysis." Osteoporos Int.
Leslie, W. D., S. L. Brennan, H. J. Prior, L. M. Lix, C. Metge and B. Elias (2012). "The post-fracture care gap among Canadian First Nations peoples: a retrospective cohort study." Osteoporos Int 23(3): 929-936.
Levinger, P., D. T. Lai, H. B. Menz, A. D. Morrow, J. A. Feller, J. R. Bartlett, N. R. Bergman and R. Begg (2012). "Swing limb mechanics and minimum toe clearance in people with knee osteoarthritis." Gait Posture 35(2): 277-281.
Levinger, P., H. B. Menz, A. D. Morrow, J. R. Bartlett, J. A. Feller, M. R. Fotoohabadi and N. R. Bergman (2012). "Dynamic foot function changes following total knee replacement surgery." Knee 19(6): 880-885.
Levinger, P., H. B. Menz, A. D. Morrow, J. A. Feller, J. R. Bartlett and N. R. Bergman (2012). "Foot kinematics in people with medial compartment knee osteoarthritis." Rheumatology (Oxford) 51(12): 2191-2198.
Levinger, P., H. B. Menz, A. D. Morrow, M. A. Perrott, J. R. Bartlett, J. A. Feller and N. B. Bergman (2012). "Knee biomechanics early after knee replacement surgery predict abnormal gait patterns 12 months postoperatively." J Orthop Res 30(3): 371-376.
Levinger, P., H. B. Menz, A. D. Morrow, E. Wee, J. A. Feller, J. R. Bartlett and N. Bergman (2012). "Lower limb proprioception deficits persist following knee replacement surgery despite improvements in knee extension strength." Knee Surg Sports Traumatol Arthrosc 20(6): 1097-1103.
Nagano, H., R. K. Begg, W. A. Sparrow and S. Taylor (2012). "A Comparison of Treadmill and Overground Walking Effects on Step Cycle Asymmetry in Young and Older Individuals." J Appl Biomech.
Nikander, R., C. Gagnon, D. W. Dunstan, D. J. Magliano, P. R. Ebeling, Z. X. Lu, P. Z. Zimmet, J. E. Shaw and R. M. Daly (2011). "Frequent walking, but not total physical activity, is associated with increased fracture incidence: a 5-year follow-up of an Australian population-based prospective study (AusDiab)." J Bone Miner Res 26(7): 1638-1647.
Nowson, C. A., P. R. Ebeling and R. S. Mason (2012). "Vitamin D and health in adults in Australia and New Zealand: a position statement." Med J Aust 197(10): 553-554.
Nowson, C. A., J. J. McGrath, P. R. Ebeling, A. Haikerwal, R. M. Daly, K. M. Sanders, M. J. Seibel, R. S. Mason and E. d. S. o. A. a. O. A. Working Group of Australian and New Zealand Bone and Mineral Society (2012). "Vitamin D and health in adults in Australia and New Zealand: a position statement." Med J Aust 196(11): 686-687.
Razak, A. H., A. Zayegh, R. K. Begg and Y. Wahab (2012). "Foot plantar pressure measurement system: a review." Sensors (Basel) 12(7): 9884-9912.
Rejnmark, L., A. Avenell, T. Masud, F. Anderson, H. E. Meyer, K. M. Sanders, K. Salovaara, C. Cooper, H. E. Smith, E. T. Jacobs, D. Torgerson, R. D. Jackson, J. E. Manson, K. Brixen, L. Mosekilde, J. A. Robbins, R. M. Francis and B. Abrahamsen (2012). "Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials." J Clin Endocrinol Metab 97(8): 2670-2681.
Sanders, K. M., G. C. Nicholson and P. R. Ebeling (2012). "Is High Dose Vitamin D Harmful?" Calcif Tissue Int.
Santhiranayagam, B. K., D. T. Lai, R. K. Begg and M. Palaniswami (2011). "Estimation of end point foot clearance points from inertial sensor data." Conf Proc IEEE Eng Med Biol Soc 2011: 6503-6506.
Scott, D., L. Blizzard, J. Fell and G. Jones (2012). "Prospective study of self-reported pain, radiographic osteoarthritis, sarcopenia progression, and falls risk in community-dwelling older adults." Arthritis Care Res (Hoboken) 64(1): 30-37.
Tirosh, O., A. Cambell, R. K. Begg and W. A. Sparrow (2012). "Biofeedback Training Effects on Minimum Toe Clearance Variability During Treadmill Walking." Ann Biomed Eng.
Torpy, A. M., S. L. Brennan, M. A. Kotowicz and J. A. Pasco (2012). "Reasons for referral to bone densitometry in men and women aged 20-49 years: population-based data." Arch Osteoporos 7(1-2): 173-178.
Tran, B., B. K. Armstrong, J. B. Carlin, P. R. Ebeling, D. R. English, M. G. Kimlin, B. Rahman, J. C. van der Pols, A. Venn, V. Gebski, D. C. Whiteman, P. M. Webb and R. E. Neale (2012). "Recruitment and results of a pilot trial of vitamin d supplementation in the general population of australia." J Clin Endocrinol Metab 97(12): 4473-4480.
Wahl, D. A., C. Cooper, P. R. Ebeling, M. Eggersdorfer, J. Hilger, K. Hoffmann, R. Josse, J. A. Kanis, A. Mithal, D. D. Pierroz, J. Stenmark, E. Stöcklin and B. Dawson-Hughes (2012). "A global representation of vitamin D status in healthy populations." Arch Osteoporos 7(1-2): 155-172.
Brennan SL, Henry MJ, Kotowicz M, Nicholson G, Zhang Y & Pasco J. 2011. Incident hip fracture and social disadvantage in an Australian population aged 50 years or greater. Bone. 48 (3): 607-610.
Brennan SL, Pasco JA, Cicuttini F, Henry MJ, Kotowicz MA, Nicholson G & Wluka A. 2011. Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong osteoporosis study. Bone. 49: 839-844.
Brennan S, Pasco J, Urquhart D, Oldenburg B, Wang Y & Wluka A. 2011. Association between socioeconomic status and bone mineral density in adults: a systematic review. Osteoporosis International. 22 (2): 517-527.
Pasco JA, Brennan SL, Henry MJ, Nicholson G, Sanders K, Zhang Y & Kotowicz MA. 2011. Changes in hip fracture rates in Southeastern Australia spanning the period 1994-2007. Journal of Bone and Mineral Research. 26: 7.
Pasco J, Brennan S, Henry M, Nicholson G, Sanders K, Zhang Y & Kotowicz M. 2011. Changes in hip fracture rates in south-eastern Australia spanning the period 1994-2007. Journal of Bone and Mineral Research. 26:
Borromeo GLB, Tsao CET, Darby IBD & Ebeling PRE. 2011. A review of the clinical implications of bisphosphonates in dentistry. Australian Dental Journal. 56 (1): 2-9.
Daly RM, Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Sikaris KA, Zimmet PZ, Ebeling PR, Shaw JE. Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: A national, population-based study. Clin Endocrinol (Oxf). 2011 Dec 15 (epub).
Ebeling PR. New drugs for osteoporosis. Aust Prescr. 2011 34:176-81.
Ebeling PR. 2011. Routine screening for vitamin D deficiency in early pregnancy: past its due date? Medical Journal of Australia. 194: 7.
Gagnon C, Lu Z, Magliano D, Dunstan D, Shaw J, Zimmet P, Sikaris K, Grantham N, Ebeling PR & Daly RM. 2011. Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years. Diabetes Care. 34: 1133-1138.
Jamal S, Ljunggren O, Stehman-Breen C, Cummings S, Mcclung M, Goemaere S, Ebeling PR, Franek E, Yang Y, Egbuna O, Boonen S & Miller P. 2011. Effects of denosumab on fracture and bone mineral density by level of kidney function. Journal of Bone and Mineral Research. 1829-1835.
Kukuljan , Nowson A, Sanders K, Nicholson GC, Seibel J, Salmon & Daly RMD. 2011. Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: An 18 month factorial design randomized controlled trial. Journal of Clinical Endocrinology & Metabolism. 955-963.
Nabipour I, Ebeling PR, Seibel MJ. Osteoporosis in Older Men. Expert Rev Endocrinol Metab. 2011 6(4): 629-645.
Nikander R, Gagnon C, Dunstan D, Magliano D, Ebeling PR, Lu Z, Zimmet P, Shaw J & Daly RM. 2011. Frequent walking, but not total physical activity, is associated with increased fracture incidence: a 5-year follow-up of an Australian population-based prospective study (AusDiab). Journal of Bone and Mineral Research. 26 (7): 1638-1647.
Yates C, Bartlett M & Ebeling PR. 2011. An atypical subtrochanteric femoral fracture from pycnodysostosis: a lesson from nature. Journal of Bone and Mineral Research. 26 (6): 1377-1379.
Yates C, Mcauley S, Grodski S, Hamblin P & Ebeling P. 2011. An elusive phaeochromocytoma. Medical Journal of Australia. 194 (1): 44-45.
Yeap B, Chubb S, Flicker L, Mccaul K, Ebeling PR, Hankey G, Beilby J & Norman P. 2011. Associations of total osteocalcin with all-cause and cardiovascular mortality in older men: the Health in Men Study. Osteoporosis International.
Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, Zimmet PZ, Sikaris K, Grantham N, Ebeling PR, Daly RM. Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years: results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study). Diabetes Care. 2011 May;34(5):1133-8. Epub 2011 Mar 23.
Moore E, Mander A, Ames D, Carne R, Sanders KM, Watters DAK. Cognitive impairment and vitamin B12: A review. International Psychogeriatrics (accepted 10th Nov 2011)
Sanders KM, Stuart AL, Williamson EJ, Jacka FN, Dodd S, Nicholson GC, Berk M. A randomised controlled trial investigating an annual high dose vitamin D3 and mental well-being: Vital D Study. Brit J Psych 2011; 198, 357-364. doi: 10.1192/bjp.bp.110.087544
Peake J, Kukujlan S, Nowson C, Sanders K, Daly R. Inflammatory cytokine responses to progressive resistance training and supplementation with fortified milk in men aged 50+ years: an 18-month randomized controlled trial; European Journal of Applied Physiology; Apr 1 (Epub ahead of print)
Williams LJ, Pasco JA, Henry MJ, Sanders KM, Nicholson GC, Kotowicz MA, et al. Paracetamol (Acetaminophen) use, fracture and bone mineral density. Bone 2011;48: 1277-1281.
Pasco JA, Brennan SL, Henry MJ, Nicholson GC, Sanders KM, Zhang Y, et al. Changes in hip fracture rates in south-eastern Australia spanning the period 1994-2007. J Bone Miner Res 2011 Mar 28. doi: 10.1002/jbmr.393.(Epub ahead of print).
Kukuljan S, Nowson C, Sanders KM, Nicholson GC, Siebel M, Salmon J, Daly R. Independent and combined effect of Calcium-Vitamin D3 Fortified Milk and Exercise on Bone Structure and Strength in Older Men: An 18-month Factorial Design RCT. JECM 2010; doi:10.1210/jc.2010-2284.
Henry MJ, Pasco JA, Merriman E, Zhang Y, Sanders KM, Kotowicz MA, Nicholson GC. Fracture risk (FRISK) score and absolute risk of fracture. Radiology; May 2011; 259(2)495-501.