The aim of this study is to determine which dosing regimen, if any, is better at achieving adequate and sustained 25 OH vit D levels in breast fed infants born to Vitamin D deficient mothers. As non-compliance rates are as high as 45%, there is a developing practice of giving a single dose of oral vitamin D 50,000iu to these newborns, yet there has been no published data to date comparing a high single dose to daily dosing in this age group. Studies have however shown that 400IU vitamin D given to fully breastfed infants, is enough to achieve significant and sustained increases in 25 OH vit D to achieve target of > 50nmol/l. This is in line with current Australasian Paediatric Endocrinology Group (APEG) guidelines. This study aims to compare daily vitamin D doses of 400IU given as “Pentavite” for the first 4 months with a single oral dose of 50,000IU (approximately equivalent to 120 days x 400iu) given to newborns. To assess safety and efficacy, 25 OH vitamin D and serum calcium will be assessed at baseline, 6 - 8 days and 3 - 4 months.
Principal Investigator: Dr Julie Huynh
This project is being undertaken as her FRACP College project as part of her paediatric training. Dr Huynh is a advanced training registrar at Sunshine Hospital
Associate Professor Christine Rodda, Paediatric Endocrinologist, Sunshine Hospital, University of Melbourne
Dr Thao Lu, Neonatologist, Sunshine Hospital
Professor Danny Liew, Statistician, University of Melbourne